In reply to Neuroxium: ["After months of community testing and raid data, this guide has been updated to remove the 2h Scourge Strike focused build, as it was considerably less damage than the 'Morb' variant."]
Basically you need to run Scourge Strike, to keep up the buff the Sigils Provide to you. Sigil of Virulence or Sigil of the Hanged Man both require to hit Scourge Strike a non zero amount of time, rotation is the same for DW and 2h. Talent build is different.